Protein Details: Gamma-aminobutyric acid receptor subunit rho-3

Protein ID

ICDB_Pro_0069

Protein Name

Gamma-aminobutyric acid receptor subunit rho-3

Gene Name

GABRR3

Organism

Homo sapiens (Human)

Length

467 amino acids

AlphaFoldDB

AF-A8MPY1-F1-model_v4.pdb

Function

Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA);the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits;where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA;rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity).

Sequence

MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQKYEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 111; /ligand="4-aminobutanoate": "ligand shared between two neighboring rho subunits"; /note="in chain A"; BINDING 175; /ligand="4-aminobutanoate": "ligand shared between two neighboring rho subunits"; /note="in chain A"; BINDING 203; /ligand="4-aminobutanoate": "ligand shared between two neighboring rho subunits"; /note="in chain B";

Disease

Restless Legs Syndrome and Autism Spectrum Disorder

Location

DOI ID

10.1038/nature04728; 10.1016/s0167-4781(99)00167-0

RefSeq

NP_001099050.1